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In the ongoing search for “the” important marker of cardiac risk, some scientists are now focusing on one you may not have heard of — and your doctor may not be evaluating. It’s a measurement called Apo B, which reveals the number of cholesterol particles in your bloodstream that can clog arteries and lead to a heart attack or stroke. This may be a more useful predictor of risk than the total cholesterol, which is what’s commonly measured. Read more

The next advance in treating major depression may relate to a group of brain chemicals that are involved in virtually all our brain activity, according to a study published today in Biological Psychiatry. The study is co-authored by Drs. Andrea J. Levinson and Zafiris J. Daskalakis of the Centre for Addiction and Mental Health (CAMH). Read more

For the approximately 7.5 million Americans affected by psoriasis, the thick, red, scaly, itchy plaques it causes only scratch the surface when it comes to the overall implications of this disease. Now, ongoing research linking psoriasis to other serious medical conditions and the incredible toll it can take on a person’s overall quality of life are shifting the way psoriasis is viewed — from a common skin disease to a complex systemic condition. Read more

Bacterial populations in the gut of diabetics differ from non-diabetics, says a new study from Denmark that may open up a potential role for modifying gut microflora with probiotics and prebiotics to improve health.

The study, published in the open-access peer-reviewed journal PLoS ONE, builds on earlier studies that have linked gut microflora and obesity. Read more

Michelle Fay Cortez

Beta amyloid that builds up in the brains of patients with Alzheimer’s disease may go along with beneficial antimicrobial activity, researchers said.

The findings from investigators at Massachusetts General Hospital raise the possibility that some cases of Alzheimer’s may stem from chronic, undetected brain infections. The results also cast doubt on the pharmaceutical industry’s efforts to find drugs to wipe out beta amyloid from the brain, one of the main methods now in development to fight the most common form of dementia in the elderly, the researchers said. Beta amyloid, or abeta, remains harmful in high concentrations, they said. Read more

Some of the nation’s leading orthopedic surgeons have reduced or stopped use of a popular category of artificial hips amid concerns that the devices are causing severe tissue and bone damage in some patients, often requiring replacement surgery within a year or two.

In recent years, such devices, known as “metal on metal” implants, have been used in about one-third of the approximately 250,000 hip replacements performed annually in this country. They are used in conventional hip replacements and in a popular alternative procedure known as resurfacing. Read more

By LAURAN NEERGAARD

What if you could be fat but avoid heart disease or diabetes? Scientists trying to break the fat-and-disease link increasingly say inflammation is the key.

In the quest to prove it, a major study is under way testing whether an anti-inflammatory drug — an old, cheap cousin of aspirin — can fight the Type 2 diabetes spurred by obesity. Read more

By ANNA WILDE MATHEWS

If you’re taking a daily aspirin for your heart, you may want to reconsider.

For years, many middle-aged people have taken the drug in hopes of reducing the chance of a heart attack or stroke. Americans bought more than 44 million packages of low-dose aspirin marketed for heart protection in the year ended September, up about 12% from 2005, according to research firm IMS Health.
Read more

Inspired by Morgan Spurlock’s fast-food gluttony in the movie Super Size Me, two environmental activists from Canada devised their own experiment. Instead of fast food, Rick Smith and Bruce Lourie absorbed themselves in everyday products like shampoos, soaps and cleaners to find out what kind of damage might be done to their health.

Their book about the adventure is called Slow Death by Rubber Duck: The Secret Danger of Everyday Things. Smith tells Guy Raz that writing the book was like conducting an adult science fair project — with one cardinal rule. Read more

By Casey Johnston

We’d like to think of ourselves as dynamic, unpredictable individuals, but according to new research, that’s not the case at all. In a study published in last week’s Science, researchers looked at customer location data culled from cellular service providers. By looking at how customers moved around, the authors of the study found that it may be possible to predict human movement patterns and location up to 93 percent of the time. These findings may be useful in multiple fields, including city planning, mobile communication resource management, and anticipating the spread of viruses. Read more

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